During aging or reduced activity, muscle mass and strength declines, and body weight may unhealthily increase.  This predisposes the animal to decreased joint stability and misalignment.  Consequently, with increased mechanical stress, degenerative inflammation sets in, deteriorating cartilage and joins.

WHEY PROTIEN CONCENTRATE:  UNTAMED HIP & JOINT is fortified with Whey Protein, a complete and nutrient-rich protein source.  Whey Protein Concentrate is rich in amino acids, which inhibit muscle degeneration, and stimulate muscle protein synthesis, helping to maintain your animal’s lean muscle mass and strength. Enhancing the strength of the muscles surrounding the joints may improve structural joint support, and decrease the risk of joint injuries^51,52.  Protein also provides amino acids for proteoglycan and collagen production, which are essential building blocks in the extracellular matrix⁵³. The extracellular matrix is present in all tissues, like the joints, muscles, tendons, cartilage, skin, and organs.  It provides structural support to the tissues and maintains proper hydration.  It is also responsible for vital biochemical and biomechanical processes involved in healthy tissue development.

CURCUMIN is well researched for its powerful anti-inflammatory actions.  And with its protective properties on cartilage⁸, it has exceptional medical value in the treatment of arthritic diseases. Research shows that highly concentrated curcumin extract stimulates the production of glycosaminoglycans, chondrocytes, and type II collagen which are involved in the formation and structural integrity of cartilage⁹.  It also inhibits inflammation-induced degeneration of cartilage and chondrocytes^13,14.  Curcumin further inhibits joint inflammation and joint destruction by inhibiting bone resorption osteoclast cells, and blocking expression of genes, inflammatory enzymes like COX-2, and other inflammatory mediators that promotes joint degeneration²⁵.

GLUCOSAMINE SULPHATE is a superior form of glucosamine due to its enhanced bio-availability. It consists of a structural amino acid, glucosamine, which is abundantly found in joint cartilage, synovial fluid in the joints, and in the intervertebral discs.   It also contains Sulphur which is required by every cell in the body for efficient function.  Sulphur is a vital element for healthy connective tissues, it is utilized in detoxification of toxins, is involved in cellular respiration, promotes healing, and helps to relieve symptoms of arthritis. Research illustrates that Glucosamine Sulphate’s efficacy is superior to Chondroitin Sulphate in arthritic conditions. It has a growth-promoting effect on cartilage, and delays cartilage degeneration by various effective antioxidant and anti-inflammatory mechanisms. Studies conclude that long term supplementation with Glucosamine Sulphate clinically benefits arthritis sufferers by reducing pain, reducing arthritis progression, enhancing joint function and mobility, and decreasing the risk of total joint replacement¹⁵

The immune system is a complex defense system against foreign substances and pathogenic microorganisms.  The immune system produces antibodies from B lymphocytes (white blood cells), which bind to, and destroy invading organisms.  These antibodies are stored in the body to recognize, and destroy a recurring pathogen more effectively during follow up invasion.  T lymphocytes destroy invading pathogens by releasing toxic chemicals. They also release messenger chemicals to attract macrophagic white blood cells which engulf and kill pathogens.  T lymphocytes regulate immune responsiveness to specific agents, and can be divided into Th1 and Th2 cells.  Th1 cells are proposed to mostly mediate immune protection against intracellular viruses and certain bacteria, destroy cancerous cells, and activate delayed hypersensitivity skin reactions. Th2 cells mediate immune protection against extracellular bacteria, parasites, allergens, and toxins. Immune dysfunction and over expression of Th1 cells may result in a proinflammatory state and organ specific autoimmunity.  Overexpression of Th2 is indicated in systemic autoimmunity and chronic allergy related conditions. 

CURCUMIN regulates Th1 and Th2 immune responses, as well as production of inflammatory mediators.  By modulating immune function and inhibiting inflammation, Curcumin demonstrates marked clinical efficacy in the treatment of osteo- and rheumatoid arthritis^26,27,49,50. 

SPIRULINA is well researched for its immune modulating activities.  It may enhance immune function by increasing cellular destruction of infectious agents, increasing antibody protection, and promoting production of other immune modulating chemicals.  Spirulina can also reduce immune system hyper-responsiveness as in the case of allergies, arthritis, and organ transplants⁵⁴. 

UNTAMED HIP & JOINT is not an ordinary joint supplement and exceeds ones highest expectations with so much more. This formula is fortified with three superfoods:  SPIRULINA, WHEY PROTEIN CONCENTRATE and KELP.  In combination with Curcumin and Boswellia extracts, Untamed Hip & Joint benefits multiple physiological systems to enhance your pet’s health to a completely new level. 

SPIRULINA has exceptional nutritional properties with its rich composition of antioxidants, protein, fatty acids, fiber, vitamins and minerals. It serves as a prebiotic, supporting a healthy digestive environment, enhances physical performance ^45,46, improves insulin sensitivity and blood glucose control^42,44, supports immune function, protecting against allergies⁴⁷, provides marked antioxidant protection, supports detoxification of toxic chemicals and heavy metals like fluoride, lead, cadmium, mercury and arsenic^34-38, promotes liver health⁴⁸, exerts neuroprotective effects, reducing the risk of cognitive decline, Alzheimer’s’ and Parkinson’s disease^39-41, and reduces systemic degenerative inflammation.  Spirulina enhances overall health and well-being, and increases protection against various chronic disease like cardiovascular disease ^42,43, skin conditions, allergies, cancer, liver disease, and joint disease ³³.

WHEY PROTEIN CONCENTRATE, like the protein provided by Spirulina, is considered a complete protein source, containing all amino acids required for healthy physiological function.  Protein is an essential component of all living cells, and a substrate for a multitude of physiological processes. 

Whey Protein have significant anti-inflammatory, antioxidant and immune modulating properties.  It enhances protection against toxins, viruses, and bacteria, reduces the risk of various cancers, promotes cardiovascular-, liver-, digestive- and hormonal health, maintains healthy skin and bone, supports healthy body weight, and promotes a sense of well-being. 

Whey protein contains amino acids which form vital structural components in muscle cells, ligaments and tendons. Insufficient protein intake predisposes the animal to poor condition, muscle wasting, osteoporosis, impaired recovery after injury or training, and decreased mental ability. Protein rich diets promote a leaner and healthy body condition, and enhance muscle protein synthesis. Sufficient protein enables your pet to improve muscle composition and physical strength, especially when combined with regular exercise ^56,57. 

KELP is a nutrient-dense seaweed, rich in minerals, proteins, antioxidants, and bioactives that are not present in terrestrial foods.  Kelp supplementation is associated with significant antiviral protection, reduced gum disease and plague formation on teeth⁶³, enhanced cardiovascular health, improved body composition, decreased risk of diabetes and metabolic syndrome, improved digestive health, neuroprotection, decreased risk of cancer, maintenance of bone mineral density, improved joint mobility, and decreased joint pain associated with arthritis^58-62. 

Turmeric is a highly valued medicinal herb. Owing to CURCUMIN, its active constituent, it has been used for thousands of years for its remarkable medicinal benefits. Unfortunately, turmeric is not absorbed very well, and one has to take a large amount of turmeric powder to be of systemic benefit.  Hence the production of 95% Turmeric extract which provides pure curcumin, with higher medicinal significance in the body.  

Actions and health benefits of Curcumin ^58-98

• Antiallergenic: Turmeric is well known as an immunomodulatory herb. Curcumin alleviates symptoms associated with allergic immune responses by regulating Th-1(inflammatory) and Th-2 cytokine (autoimmunity/allergy) responses, inhibiting IgE levels, and inhibiting mast cell degranulation which releases histamine.  These properties give curcumin great potential for clinical management of allergic reactions like asthma, food allergies and allergy related skin conditions. 
• Antimicrobial:  Curcumin provides broad-spectrum antimicrobial protection against bacteria like Staphylococcus epidermis, Staphylococcus aureus, Klebsiela pneumoniae, Helicobacter pylori,  Escherichia coli, Salmonella and many others; viruses like influenza viruses, herpes, coxsackie, hepatitis viruses, papilloma viruses, encephalitis viruses and many more; fungi like Cryptococcus neoformans, Candida albicans, and other skin fungi like T rubrum, T. mentagrophytes, E. floccosum and M. gypseum, and parasites Schistosomas, Toxocara canis, Eimeria species, Plasmodium, Trypanosoma, Giardia lamblia, Leishmania and Cryptosporidium. 
• Powerful anti-inflammatory and antioxidant:  Curcumin reduces inflammation by multiple mechanisms like inhibiting pro-inflammatory signaling, inhibiting immune cell migration to the active site of inflammation, and reducing excessive existing inflammation by decreasing the activity of inflammatory enzymes.
• Neuroprotective:  Curcumin can protect nerve cells against inflammation and degeneration caused by multiple pathological agents including toxins, stress related high cortisol levels, and age-related degenerative conditions like Alzheimer’s and Parkinson’s disease.
• Protect against heart disease:  Curcumin provides protection against cardiac hypertrophy, inflammation, atherosclerosis, blood clot formation and high cholesterol.
• Antidiabetic: Curcumin illustrates promising protection against insulin resistance, diabetes and its associated inflammatory pathways.
• Antiarthritic:  Curcumin is well researched for its powerful anti-inflammatory actions which, in addition to its protective properties on cartilage, adds exceptional medical value to this plant extract for the treatment of arthritic diseases. Research shows that a highly-concentrated curcumin extract stimulates the production of glycosaminoglycans and chondrocytes, which are involved in the formation and structural integrity of cartilage.  Curcumin supplementation can reduce joint pain, enhance articular function, and improve quality of movement.
• Anticancer:  Research illustrates that high dose of concentrated Curcumin extract can inhibit the growth of various cancers and enhance the anticancer effects of chemotherapy drugs and radiation.  Curcumin, may alleviate the risk of cancer by supporting the natural defense mechanisms of a mammal by increasing antioxidant protection, inhibiting inflammatory degeneration, enhancing liver detoxification by down-regulating Phase I and enhancing Phase II detoxification of cancer-causing agents like cigarette smoke, benzopyrene, and DMBA, and inhibiting cancer cell development and spreading.
• Accelerates wound healing: Curcumin exerts a significant wound healing effect owing to its anti-oxidant, anti-inflammatory, anti-infectious, and immune-modulating characteristics. Curcumin targets various stages of wound healing. It promotes the removal of dead tissue from the site of injury, formation of new blood vessels in that area, granulation tissue, deposition of collagen for increased tissue strength and integrity, and wound closure.
• Enhances skeletal muscle repair: Soft tissue injury is most often related to a sport injury.  The results are swelling, bruising, severe pain, and ultimately diminished muscle function & performance.  The repair process involves tissue degeneration, inflammation, regeneration, and scar tissue formation.  Curcumin promotes healthy muscle repair by supporting balanced and efficient anti-inflammatory-, immune- and anti-oxidant responses,which enhances muscle cell regeneration and accelerates recovery. By modulating inflammation, reducing lactate accumulation and reducing pain following intensive exercise, curcumin facilitates a faster return to training and increases the capacity for higher training intensity.
• Supports healthy digestive function: Curcumin provides significant anti-inflammatory protection in the digestive tract, alleviating inflammatory damage, abdominal pain and gastric discomfort associated with IBS (irritable bowel syndrome), ulcerative colitis, Crohn’s disease and H. pylori- induced ulcers.

 BOSWELLIA

Boswellic acid, a constituent of Boswellia, has potent anti-inflammatory, expectorant, antiseptic, pain-relieving, antibacterial, anti-anxiety, and anti-neurotic properties.  Clinical studies indicate that Boswellic acids have the ability to modulate many mediators involved in disease progression. It exhibits clinical efficacy in the treatment of conditions like: arthritis, Alzheimer’s disease, asthma, various cancers and tumours, cognitive impairment, atherosclerosis, inflammatory bowel disease, ulcerative colitis, irritable bowel syndrome, bronchitis, sinusitis, diabetes, central nervous system disorders, and psoriasis.^99-100

INDICATIONS

• Protects Joint Health In Healthy-, Active- or Aging Pets
• Eases Mobility, Swelling, Stiffness & Pain In Limbs & Joints
• Targets Inflammation & Enhances Recovery Following Injuries

SUGGESTED USE
Mix the suggested serving size with some water or broth into a liquid, and mix into dry kibble or raw food.
Small pets (<10KG): 1/4 teaspoon 2x daily
Medium size pets (10KG-20KG): 1/4 – 1/2 rounded teaspoon 2x daily
Larger pets (20-40KG): 1/2 – 1 teaspoon, 2x daily
X-Large pets (40KG+): 1 rounded teaspoon (3.3g), 2x daily

30-120 days supply (depending on the size of your pet).One 200g tub will last a large dog 40 days.

PLEASE TAKE CARE
Avoid concurrent use with anti-coagulant medication. Discontinue use two weeks before surgery. Not recommended for animals with gallstones, or over-active thyroid. Not for use during pregnancy or nursing. Discontinue use in case of an allergic reaction. This product nor its information, is intended to substitute the professional advice or prescription of your veterinarian, and does not claim to treat, cure or prevent disease. Store at cool, dry temperatures. Keep out of reach of children.

SIDE EFFECTS
Excessively large servings may cause gastrointestinal upset, heartburn and headaches. Reduce the serving size, or in case of an allergic reaction, avoid use.

*In case of accidental overconsumption, contact your veterinarian immediately.